Clofarabine triphosphate
WebApr 19, 2024 · Clofarabine triphosphate was found to be a potent inhibitor of the incorporation of dATP by DNA polymerase α, with a K i value of approximately 1 μM (K m for dATP was 4 μM), but it was a weak inhibitor of DNA polymerase β (involved in DNA repair) and γ (involved in mitochondrial DNA synthesis). WebCLOLAR®(clofarabine) injection, for intravenous use Initial U.S. Approval: 2004 INDICATIONS AND USAGE Clolar is a nucleoside metabolic inhibitor indicated for the …
Clofarabine triphosphate
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WebThe actions of clofarabine triphosphate on ribonucleotide reductase and incorporation in the DNA repair patch suggest that a mechanism-based combination with arabinosyl- cytosine and DNA-damaging agents would be effective. Combination clinical trials have been conducted, while new trials are underway. Keywords Acute leukemia WebThe population pharmacokinetics of plasma clofarabine and intracellular clofarabine triphosphate were characterized in pediatric patients with acute leukemias. Traditional model-building techniques with NONMEM were used.
WebClofarabine triphosphate C10H14ClFN5O12P3 CID 9915350 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, … WebClofarabine is metabolized intracellularly to the active 5'-monophosphate metabolite by deoxycytidine kinase and 5'-triphosphate metabolite by mono- and di-phospho-kinases. …
WebMar 24, 2016 · Clofarabine is an FDA approved RNR inhibitor (RNRI) used in the treatment of acute lymphoblastic leukemia. As a purine nucleoside analog (Fig. 1 a), clofarabine is transported into cells by nucleoside transporters and is phosphorylated by host enzymes to the active forms of the drug, clofarabine di- and triphosphate [ 18 ]. WebFeb 1, 2005 · As clofarabine is a potent inhibitor of ribonucleotide reductase (RnR), we hypothesized that clofarabine will modulate ara-c triphosphate accumulation and increase the antileukemic activity of cytarabine (ara-C).
WebNCATS Inxight Drugs — Clofarabine triphosphate ... Chemical
Web英文别名: Clofarabine Triphosphate Triethylamine Salt: CAS号: 134646-41-6: SMILES: C1=NC2=C(N=C(N=C2N1[C@H]3[C@H]([C@@H]([C@H](O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O ... city of covington gas departmentWebFinally, clofarabine triphosphate directly induces programmed cell death by causing the release of numerous apoptotic compounds . The pharmacologic effects and activation of clofarabine are predominantly dependent on dCK phosphorylation. dCK is a key enzyme in the deoxyribonucleoside salvage pathway. It phosphorylates free nucleosides such as ... don horne chester nsWebPhosphorylated to form clofarabine triphosphate, which competes with dATP for DNA polymerase-alpha and -epsilon and potently inhibits ribonucleotide reductase (IC50 = 65 nM). Induces apoptosis by directly altering mitochondrial transmembrane potential. Demonstrates growth inhibition and cytotoxic activity in a variety of leukemias and solid … city of covington ga ordinancesWebAug 1, 2014 · Clofarabine triphosphate is an intracellular active metabolite of clofarabine. In the present study, we developed and validated a rapid, sensitive, and selective liquid … city of covington ga utilities paymentWebScribd adalah situs bacaan dan penerbitan sosial terbesar di dunia. city of covington ga utilities bill payWebOct 16, 2004 · Clofarabine has proven to be effective in the treatment of adult and pediatric acute myelogenous leukemia (AML). To investigate if clofarabine could be used with … city of covington ga water billWebJul 14, 2024 · Clofarabine inhibits DNA synthesis by decreasing cellular deoxynucleotide triphosphate pools through an inhibitory action on ribonucleotide reductase, and by … don horner facebook