WebSep 16, 2024 · Baseline plasma analysis for 7 ESR1 LBD mutations (E380Q, L536R, Y537C, D538G, S436P, Y537N, Y537S) in a subset of 161 patients revealed plasma ESR1 mutations in 39.1% of the patients. These patients had decreased benefit from exemestane when compared to a fulvestrant containing regimen (combining the two fulvestrant arms … WebJun 6, 2016 · Purpose ESR1 mutations are selected by prior aromatase inhibitor (AI) therapy in advanced breast cancer. We assessed the impact of ESR1 mutations on sensitivity to standard therapies in two phase III randomized trials that represent the development of the current standard therapy for estrogen receptor–positive advanced …
Implications of ESR1 Mutations in Hormone Receptor-Positive …
Given the extensive pre-clinical profiling of ESR1 mutations and their intrinsic ET resistance, many ET-treated cohorts have been screened for ESR1 mutations (Table 1). NGS identified ESR1 mutations that occurred preferentially in metastatic patients, with ESR1 mutations in 12% of metastatic tumours (9/76) versus … See more The selection of ET in MBC is particularly important, as several studies indicate that ESR1 mutations are acquired with AI therapy in MBC. In … See more To improve the therapeutic response, the use of a CDK4/6 inhibitor in combination with first- or second-line ET is now recommended for … See more While MBC patients acquire ESR1 mutations with greater frequency when treated with AIs and these ESR1 mutations are associated with decreased PFS, the role of … See more Several targeted therapy candidates for MBC treatment have been investigated for the emergence of ESR1 mutations and therapeutic efficacy. Both JQ1 (bromodomain and … See more WebSeveral large-scale clinical trials have investigated the prevalence of ctDNA ESR1 mutations in ER+ MBC patients ( 27 – 30 ). In a secondary-analysis to the BOLERO-2 study, ESR1 D538G and Y537S mutations were found in 28.8% and 13.3% of the samples, respectively ( 27 ). blue meets green st clair county
Immunohistochemical analysis of estrogen receptor in breast …
WebWe developed and analytically validated a highly sensitive and specific NaME-PrO-assisted ARMS (NAPA) assay for the detection of four ESR1 mutations (Y537S, Y537C, Y537N and D538G) in circulating ... WebNov 30, 2024 · Interestingly, the ESR1 Y537S mutation was present in wt-SUM44 at an apparent frequency of ~1:1.000.000 (Fig. 1d), implying that … WebESR1 p.Y537S Reference Standard. ESR1, estrogen receptor alpha, modulates response to estrogen and is used as a marker to predict response to endocrine therapy in breast … blue megaphone clip art