H1993 mutation

Author: cauw

August undefined, 2024

WebOct 1, 2011 · EBC-1 and H1993 cell lines were previously shown to manifest high-level amplification of MET (copy number, >10). 15 Sequencing of all 21 coding exons of MET also previously revealed that H2122 cells contain an N375S mutation and that H1437 and H596 cells harbor a deletion of exon 14 of this gene. 10, 11. Growth Inhibition Assay In Vitro WebH1993 is a c-MET amplified cell line showing c-MET and HER1 pathway activation and responsiveness to c-MET inhibitor treatment. IGF-1R pathway activated H358 and A549 …

H1993 Human Lung Adenocarcinoma Cell Line Harboring Met …

WebJan 22, 2024 · Both statins activated caspase 3 significantly at 50 or 100 µM in Calu6 or A549 cells, but failed to do so in H1993 cells (Fig. 1A–C ). However, the co-administration of mevalonic acid (Mev)... WebApr 3, 2024 · Background Genetic alterations, including mutation of epidermal growth factor receptor or v-Ki-ras2 kirsten rat sarcoma viral oncogene homolog and fusion of … can you homeschool other people\u0027s kids

Genomic profiling of cell lines reveals hidden research bias

WebFont size indicates the frequency of mutations of each gene within this model's cancer type. Variants include both germ line predisposition variants and somatic driver mutations. Where both mutations and copy number alterations are observed in the same gene, the mutations colour coding is used. ... NCI-H1993 and NCI-H2073 were derived from the ... WebApr 3, 2024 · Molecular subsets of non-small cell lung cancer (NSCLC) have been defined by various types of driver gene mutations involving epidermal growth factor receptor ( EGFR ), v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog ( KRAS ), and anaplastic lymphoma kinase (ALK) gene fusion. WebMar 7, 2024 · HLA-A2-positive LUAD H1993 cells were incubated with calcein-AM (1 μm/L) for 30 min. After washing, a 1×10 5 cells/ml tumor cell suspension was prepared. Transwell 24-well plates were taken, and A and B treatment groups, positive control group, and background control group were set up. brightspeed return

Signatures of Drug Sensitivity in Nonsmall Cell Lung Cancer

Effects of Ephedra Herb extract on the expression of EGFR

WebHuman Mutation. 2015;37:235-241. Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Human … WebTo cite this cell line use: NCI-H1993 (RRID:CVCL_1512) Comments. Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). Part of: COSMIC cell lines project. Part of: MD Anderson Cell Lines Project. Population: Caucasian. Doubling time: 31.6 hours (PubMed= 29681454 ). can you homeschool in virginiaWebFeb 25, 2005 · Abstract. Non–small cell lung cancer (NSCLC) is a difficult disease to treat. The c-Met receptor is an attractive potential target for novel therapeutic inhibition in … brightspeed return instructions

"WebCopy Number Public 22Q4 Hotspot Mutations Damaging Mutations Mutation. Compound Viability screens Drug sensitivity AUC (Sanger GDSC1) Drug sensitivity AUC (Sanger … " - H1993 mutation

H1993 mutation

Cellosaurus cell line NCI-H1993 (CVCL_1512)

http://psb.stanford.edu/psb-online/proceedings/psb14/mayba.pdf WebMar 5, 2024 · Met crosstalk with the EGFR family converges on HER3 in MET-amplified cells. To understand the crosstalk signaling axis between Met and EGFR family RTKs, we assembled a panel of MET-amplified cancer cell lines, derived from esophageal (OE33), gastric (KatoII, Okajima, Snu5, MKN45) and lung (EBC1, H1993) …

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WebFeb 17, 2024 · Combination of ILEI knock-down and c-MET-inhibition significantly reduced the invasive outgrowth of NCI-H441 and NCI-H1993 lung tumor xenografts by inhibiting proliferation, MMP expression and E-cadherin membrane localization. ... This can be the result of a mutation that switches an oncogene on permanently or from overexpression … WebH1993, A549, PC9, HCC827 and H1975 are human NSCLC cell lines, and Beas-2B an immortalized human lung bronchial epithelial cell line. We designed EGFR wild type cell lines (H1993, A549, Beas-2B) as control groups and EGFR mutant cell lines (PC9, HCC827, H1975) as experimental groups. ... EGFR mutation cells count on lipids to survive and …

Web64 rows · Cancer Cell Lines with Mutant KRAS Genes. The heterogeneity of human cancers is a major obstacle to developing therapies. One way of dealing with that heterogeneity is … WebMar 19, 2024 · To analyze only non-synonymous mutations including truncating mutation and deleterious missense mutation, we excluded neutral mutations predicted from two algorithms. The criteria of non-synonymous mutations are SIFT score < 0.05 or Polyphen-2 score > 0.85. Gene expression data were integrated with these processed mutation data.

WebThe preexisting carcinoma cell line mutation landscape could determine its response to particular molecular biology manipulation, such response could be inconsistent. However, only consistent results would be reported. Moreover, since genotype determined phenotype, identifying the genotype of carcinoma cell line is critical to the research result. WebMutations occur particularly in lung and colorectal cancer. Most of the somatic LKB1 mutations result in truncation of the protein. A mutational hotspot seems to be a C6 …

WebApr 12, 2024 · We previously reported that the combined application of Ephedra Herb extract (EHE) and epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI), erlotinib, is effective in suppressing the growth of erlotinib-resistant non-small-cell lung cancer (NSCLC) cell line, H1993, xenograft tumor, and cell proliferation, and that EHE …

Weband RNA-Seq data on the two cell lines allowed us to reduce a set of non-synonymous mutations to two likely drivers of oncogenesis in this patient. While 106 non … can you homeschool other person childWebCell line H1993 was derived from the lymph nodes of a 47 year old female Caucasian with history of smoking and diagnosed with non-small cell lung cancer in 1988 (Figure 1A). After treatment with cisplatin and etoposide, H2073 was derived from the resected lung tumor of the same patient. brightspeed return labelWebErl; J, H1993-Gef or H1993-Erl) were treated with YD for 24 hr, and then miR-139-5p levels were analyzed by Taqman assay as described in the Materials and Methods. (K) Relative expression of miR-139-5p in the indicated xenografts. can you homeschool part timeWebFeb 1, 2012 · In the analysis of malignant pleural effusions, EGFR mutations were detected only by PNA clamping in four of nine patients who exhibited partial response to EGFR tyrosine kinase inhibitors; all the cell blocks of these four … can you homeschool other person child uWebJun 1, 2015 · Human NSCLC cell lines A549, PC9, HCC827, H1975, H1993, and an immortalized human lung bronchial epithelial cell line (Beas-2B) were purchased from the American Type Culture Collection. ... Peripheral blood from 20 consecutive EGFR mutation NSCLC patients before and after EGFR-TKIs treatment for 1 month was obtained in Sun … can you homeschool without a degreeWebNov 7, 2024 · A549, H23, H1993, and H322M cells were obtained from the National Institutes of Health, National Cancer Institute (NCI, USA). HCC-827 and H1975 cells were obtained from the American Type Culture Collection (ATCC, USA). ... In these qPCR experiments, cell lines harboring STK11 mutations (A549, H23, and H1993) displayed > … can you homeschool your child at any timeWebWe previously reported that the combined application of Ephedra Herb extract (EHE) and epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI), erlotinib, is effective in suppressing the growth of erlotinib-resistant non-small-cell lung cancer (NSCLC) cell line, H1993, xenograft tumor, and cell proliferation, and that EHE … can you homeschool your child if you work