Tedanolide
WebIn addition, the synthesis of iso-tedanolide will provide a unique opportunity to explore the feasibility of a 1,5-acyl migration, a key step in a proposed biogenic pathway to the tedanolides. Biological analyses will be carried out under the direction of Dr. Florenz Sasse at the Helmholtz Zentrum fuer Infektionsforschung (HZI Braunschweig). WebTedanolide C32H50O11 - PubChem Apologies, we are having some trouble retrieving data from our servers... PUGVIEW FETCH ERROR: 403 Forbidden National Center for Biotechnology Information 8600 Rockville Pike, Bethesda, MD, 20894 USA Contact Policies FOIA HHS Vulnerability Disclosure National Library of Medicine National Institutes of Health
Tedanolide
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WebSep 16, 1999 · Synthetic Studies of Tedanolide, a Marine Macrolide Displaying Potent Antitumor Activity. Stereoselective Synthesis of the C (13)−C (23) Segment. Organic Letters 2005, 7 (12) , 2341-2344. DOI: 10.1021/ol050569a. Lisa D. Julian,, Jason S. Newcom, and, William R. Roush. Total Synthesis of (+)-13-Deoxytedanolide. WebTedanolide. Molecular Formula C 32 H 50 O 11; Average mass 610.733 Da; Monoisotopic mass 610.335327 Da; ChemSpider ID 10290363 - Double-bond stereo - 13 of 13 defined stereocentres. More details: Systematic name
Webtedanolide skeleton by cleavage at the lactone moiety and at the C12-C13 bond affords the intermediates 3 and 4, which could be combined in the forward sense by either an aldol reaction of the aldehyde derived from 3 (for tedanolide 1) or an alkylation of the tosylate derived from 3 (for deoxytedanolide 2) followed by removal of protecting Webapproaches to tedanolide and its analogues. By using a straightforward retrosynthetic disconnection of the tedanolide skeleton involving cleavage at the lactone moiety and …
http://www.chem.ucla.edu/~jung/pdfs/254.pdf WebThe C1-C12 part (4) of tedanolide (1) was synthesized starting from methyl (R)-3-hydroxy-2-methylpropionate (11a) via a coupling between the C1-C7 aldehyde (6) and the C8-C11 …
WebTedanolide is a marine natural product isolated from sponge Tedania ignis by Schimtz et al. in 1984.1,2 The sponge showed potent cytotoxicity and in vivo tumor inhibition activity. The isolation process is shown in Scheme 1.1. Notice the extreme low isolated yield of tedanolide, which suggests that it may be a metabolite of some ...
Webapproaches to tedanolide and its analogues. By using a straightforward retrosynthetic disconnection of the tedanolide skeleton involving cleavage at the lactone moiety and scission at the C12-C13 bond, we were able to generate the precursors 2 and 3 (Scheme 1). Recently, we reported two approaches to the C1-C12 fragment of tedanolide 2, both of ... tour porscheWebFeb 21, 2008 · Tedanolide represents a group of natural products which exhibit a primary hydroxyl group incorporated in the lactone moiety. We describe the … pound korean wonWebMay 1, 2002 · Tedanolide C: A Potent New 18-Membered-Ring Cytotoxic Macrolide Isolated from the Papua New Guinea Marine Sponge Ircinia sp.. The Journal of Organic … poundland 1990WebSep 11, 2006 · Tedanolide (1), an antitumor macrolide, was isolated from a prevalent Caribbean sponge, Tedania ignis, by Schmitz et al. 1 Tedanolide is highly cytotoxic, exhibiting ED 50 values of 250 pg/mL in KB cell lines and 16 pg/mL in PS cell lines. 1 It also shows in vivo antitumor activity increasing the lifespan of mice implanted with … poundland £2 christmas mugsWebNov 25, 2015 · Thesis title: “Progress Towards the Total Syntheses of Tedanolide and 13-Deoxytedanolide” Advisor: Professor Amos B. Smith, III American Chemical Society Division of Organic Chemistry Graduate ... poundland 2022poundland 2022 diaryWebTedanolide C was isolated by the group of Chris M. Ireland from marine sponge Ircinia sp. collected in Milne Bay, Papua New Guinea. It shows a remarkable cytotoxic profile against HCT-116 cells at 95.3 nM. Like tedanolide and 13-deoxytedano-lide it could serve as an inhibitor of protein biosynthesis. The configuration of tedanolide C was ... pound kwacha